clinical effects of a microdose gnrh agonist flare regimen administered to poor responders undergoing art cycles
نویسندگان
چکیده
the microdose gnrh agonist (gnrh-a) flare protocol may have a particular value for previously poor responders in whom it has been observed to stimulate dramatic increases in serum fsh. the purpose of this study was to determine the effects of microdose gnrh-a in poor responders. this is a clinical trial with before and after design. this study was done in research and clinical center for infertility (shahid sadoughi university, yazd, iran) and madar hospital, yazd, iran. in this study, 61 poor responders volunteered for in vitro fertilization (ivf) or intracytoplacmic sperm injection (icsi). the volunteers were divided into two age groups (group a, 20 - 34; group b, 35 - 40) and received low dose oral contraceptive pills for 21 days, then 40µg of subcutaneous buserelin 2 times/day from day 3 of the cycle and human menopausal gonadotropin (hmg) 3 ampoules/day from day 5. main outcome measures were number of follicles, oocytes and embryos, and pregnancy rate (pr). these measures were then compared with those of the previous cycle. there were significant differences in all parameters (p < 0.05). pregnancy occurred in 3 women (5%). there was no significant difference in number of follicles, oocytes and embryo between two age groups (p > 0.05). use of microdose gnrh-a plus hmg for controlled ovarian hyperstimulation in ivf or icsi cycles can lead to formation of more follicles, oocyte and embryo in poor responders.
منابع مشابه
Microdose GnRH Agonist Flare-Up versus Ultrashort GnRH Agonist Combined with Fixed GnRH Antagonist in Poor Responders of Assisted Reproductive Techniques Cycles
متن کامل
Microdose Flare-up Gonadotropin-releasing Hormone (GnRH) Agonist Versus GnRH Antagonist Protocols in Poor Ovarian Responders Undergoing Intracytoplasmic Sperm Injection
BACKGROUND Microdose flare-up GnRH agonist and GnRH antagonist have become more popular in the management of poor ovarian responders (POR) in recent years; however, the optimal protocol for POR patients undergoing in vitro fertilization has still been a challenge. METHODS In this observational study design, two hundred forty four poor ovarian responders were retrospectively evaluated for thei...
متن کاملmicrodose flare-up gonadotropin-releasing hormone (gnrh) agonist versus gnrh antagonist protocols in poor ovarian responders undergoing intracytoplasmic sperm injection
background: microdose flare-up gnrh agonist and gnrh antagonist have become more popular in the management of poor ovarian responders (por) in recent years; however, the optimal protocol for por patients undergoing in vitro fertilization has still been a challenge. methods: in this observational study design, two hundred forty four poor ovarian responders were retrospectively evaluated for thei...
متن کاملMicrodose GnRH Agonist Flare-Up versus Ultrashort GnRH Agonist Combined with Fixed GnRH Antagonist in Poor Responders of Assisted Reproductive Techniques Cycles
BACKGROUND This study compares the microdose flare-up protocol to the ultrashort gonadotropinreleasing hormone (GnRH) agonist flare combined with the fixed multidose GnRH antagonist protocol in poor responders undergoing ovarian stimulation. MATERIALS AND METHODS In this randomized clinical trial, 120 women who were candidates for assisted reproductive techniques (ART) and had histories of on...
متن کاملmicrodose gnrh agonist flare-up versus ultrashort gnrh agonist combined with fixed gnrh antagonist in poor responders of assisted reproductive techniques cycles
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متن کاملA Flexible Multidose GnRH Antagonist versus a Microdose Flare-Up GnRH Agonist Combined with a Flexible Multidose GnRH Antagonist Protocol in Poor Responders to IVF
OBJECTIVE To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH antagonist protocol in poor responders to in vitro fertilization (IVF). STUDY DESIGN A retrospective study in Akdeniz University, Faculty of Medicine, Department of Obstetrics and ...
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عنوان ژورنال:
acta medica iranicaجلد ۴۷، شماره ۴، صفحات ۲۶۳-۲۶۷
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